The outbreak of the Israel-Hamas war raised considerably the tensions in the Middle East. Given this context, advancements in the JCPOA seems improbable, because this would include the return of the US to the agreement.
US has been fully committed in supporting Israel whose main potential enemy in the region is Iran. So, for both US and Iran, the moment is very unfavourable for advancements in this agenda, which I understand is a necessary condition for Iran to abide to IAEA requirements.
Why do you think you're right?
The protests aren't large enough to make such a powerful figure to flee the country. Furthermore, the Israel-Hamas conflict tends to strenghthen Iran's internal forces around the tensions against Israel and the solidarity for the Palestianians.
There are rumors on Khamenei's health, but that is expected from anyone in their 80s (France24).
Why might you be wrong?
Among the options for resolution. Death is the most probable. It the Ayatollah Khamenei were very ill, it would be expected for it to be kept in secreat.