Advances in DNA-sequencing technologies have dramatically expanded our ability to quickly and accurately engineer biological systems. As the cost of genome sequencing decreases, researchers can develop new applications that take advantage of this technology and use their understanding of genomics to manufacture catalogued DNA sequences and assemble them into new genomes. Some compare the cost of genome sequencing to costs to what we might expect through an application of Moore’s Law and have found that the advances have been much more rapid than anticipated. Having crossed the $1000 threshold in 2019, many are now eyeing the $100 genome as the next big milestone, with some companies already claiming that their technologies can sequence a human genome at that price.